Researchers discover biomarker for devastating intestinal disease found in early preterm infants

Researchers discover biomarker for devastating intestinal disease found in early preterm infants

Tuesday, April 16, 2013

Researchers have discovered a biomarker that may help prevent a devastating intestinal disease that occurs in one of every 10 early preterm infants.

The Cincinnati Children's Hospital Medical Center study may help prevent necrotizing enterocolitis (NEC), a condition primarily seen in preemies in which bowel tissue dies. The death rate approaches 30 percent. Survivors are at risk for short-bowel syndrome (caused by surgical removal of the small intestine) and neurodevelopmental disability.

The study is published in the journal Microbiome.

The research, led by Ardythe Morrow, PhD, shows that NEC is preceded by two distinct microbial imbalances in the digestive tract, suggesting that these imbalances "may provide highly predictive biomarkers of NEC," she says.

"Using a combination of early microbial factors, we obtained a predictive value for NEC exceeding 80 percent," says Dr. Morrow. "This requires validation in larger studies, but the findings are striking."

Dr. Morrow's main analysis looked at stool and urine samples collected from 32 infants prior to the onset of disease. The infants were born at less than 29 weeks gestational age.

Eleven of the 32 went on to develop NEC. In all of these cases, NEC was preceded by a dominance of certain types of bacteria in the intestinal tract ? either firmicutes in the first week of life or proteobacteria in the second week. Dominance of proteobacteria also occurred in half of those who did not develop NEC.

The team of investigators led by Dr. Morrow also identified a potential simple urine analysis that could help detect the bacterial dominance that occurs in advance of NEC. The research team will attempt to validate its findings in a national study and is studying approaches to prevent the occurrence of NEC in preterm infants.

###

Cincinnati Children's Hospital Medical Center: http://www.cincinnatichildrens.org

Thanks to Cincinnati Children's Hospital Medical Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 22 time(s).

Source: http://www.labspaces.net/127748/Researchers_discover_biomarker_for_devastating_intestinal_disease_found_in_early_preterm_infants

jillian michaels Freddy E NHL lockout Honey Boo Boo pirate bay Psalms 91 once upon a time